The mixed refrigerant liquid nitrogen machine is based on a regenerative throttling refrigeration cycle. From ambient temperature to target refrigeration temperature, high, medium and low boiling point pure components are preferably composed of multiple mixed refrigerants, so that the effective cooling temperature areas overlap with each other. In this way, the cooling temperature zone distribution matching is perfected, and the effective cooling temperature zone matching of each boiling point component is realized, thereby realizing high-efficiency refrigeration with a large temperature span, and a relatively high throttling refrigeration effect can be obtained under a relatively small pressure difference. Therefore, a mature single-stage refrigeration compressor in the general cold field can be used to drive a closed-cycle mixed refrigerant throttling refrigerator to achieve low-temperature refrigeration.